Izolacja retrowirusa limfotropowego T od pacjenta z nabytego niedoboru
Retrowirus należący do rodziny niedawno odkrytych ludzkich wirusów białaczki T- komórkowej (HTLV), ale wyraźnie różniący się od każdego poprzedniego izolatu, został wyizolowany od pacjenta rasy kaukaskiej z oznakami i objawami, które często poprzedzają zespół nabytego niedoboru odporności (AIDS). Wirus ten jest typowym wirusem nowotworu RNA typu C, pączkującym z błony komórkowej , preferuje magnez dla aktywności odwrotnej transkryptazy i ma wewnętrzny antygen (p25) podobny do p24 HTLV.
Przeciwciała z surowicy tego pacjenta reagują z białkami wirusów z podgrupy HTLV-I, ale antysurowice swoiste dla HTLV-I nie wytrącają białek nowego izolatu. Wirus od tego pacjenta został przeniesiony do limfocytów krwi pępowinowej , a wirus wytwarzany przez te komórki jest podobny do oryginalnego izolatu. Z tych badań wyciągnięto wniosek, że ten wirus, jak również poprzednie izolaty HTLV, należą do ogólnej rodziny retrowirusów T-limfotropowych, które są przenoszone horyzontalnie u ludzi i mogą być zaangażowane w kilka zespołów patologicznych, w tym AIDS.
Wykrywanie i izolacja retrowirusa typu C ze świeżych i hodowanych limfocytów pacjenta ze skórnym chłoniakiem T-celwym.
Retrovirus particles with sort C morphology had been present in two T-cell lymphoblastoid cell traces, HUT 102 and CTCL-3, and in recent peripheral blood lymphocytes obtained from a affected person with a cutaneous T-cell lymphoma (mycosis fungoides). The cell traces constantly produce these viruses, that are collectively known as HTLV, pressure CR(HTLV(CR)). Initially, the manufacturing of virus from HUT 102 cells required induction with 5-iodo-2′-deoxyuridine, however the cell line grew to become a constitutive producer of virus at its 56th passage. Cell line CTCL-Three has been a constitutive producer of virus from its second passage in tradition.
Each mature and immature furthercellular virus particles had been seen in thin-section electron micrographs of fastened, pelleted cellular materials; every so often, typical sort C budding virus particles had been seen. No type of intracellular virus particle has been seen. Mature particles had been 100-110 nm in diameter, consisted of an electron-dense core surrounded by an outer membrane separated by an electron-lucent area, banded at a density of 1.16 g/ml on a steady 25-65% sucrose gradient, and contained 70S RNA and a DNA polymerase exercise typical of viral reverse transcriptase (RT; RNA-dependent DNA nucleotidyltransferase). Beneath sure circumstances of assay, HTLV(CR) RT confirmed cation choice for Mg(2+) over Mn(2+), distinct from the traits of cellular DNA polymerases purified from human lymphocytes and the RT from most sort C viruses.
Antibodies to cellular DNA polymerase gamma and anti-bodies in opposition to RT purified from a number of animal retroviruses didn’t detectably work together with HTLV(CR) RT underneath circumstances that had been constructive for the respective homologous DNA polymerase, demonstrating a scarcity of shut relationship of HTLV(CR) RT to cellular DNA polymerases gamma or RT of those viruses. Six main proteins, with sizes of roughly 10,000, 13,000, 19,000, 24,000, 42,000, and 52,000 daltons, had been obvious when doubly banded, disrupted HTLV(CR) particles had been chromatographed on a NaDodSO(4)/polyacrylamide gel. The variety of these particle-associated proteins is in step with the anticipated proteins of a retrovirus, however the sizes of some are distinct from these of most recognized retroviruses of the primate subgroups.
U myszy z niedoborem interleukiny 10 rozwija się przewlekłe zapalenie jelit.
Interleukin-10 (IL-10) impacts the expansion and differentiation of many hemopoietic cells in vitro; specifically, it’s a potent suppressor of macrophage and T cell capabilities. In IL-10-deficient mice, generated by gene focusing on, lymphocyte improvement and antibody responses are regular, however most animals are development retarded and anemic and endure from power enterocolitis. Alterations in gut embody in depth mucosal hyperplasia, inflammatory reactions, and aberrant expression of main histocompatibility advanced class II molecules on epithelia.
In distinction, mutants saved underneath particular pathogen-free circumstances develop solely a neighborhood irritation restricted to the proximal colon. These outcomes point out that the bowel irritation within the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is a vital immunoregulator within the intestinal tract.
Prosta technika ilościowego określania niskich poziomów uszkodzeń DNA w poszczególnych komórkach.
Human lymphocytes had been both uncovered to X-irradiation (25 to 200 rads) or handled with H2O2 (9.1 to 291 microM) at Four levels C and the extent of DNA migration was measured utilizing a single-cell microgel electrophoresis method underneath alkaline circumstances. Each brokers induced a big enhance in DNA migration, starting on the lowest dose evaluated.
Migration patterns had been comparatively homogeneous amongst cells uncovered to X-rays however heterogeneous amongst cells handled with H2O2. An evaluation of restore kinetics following publicity to 200 rads X-rays was performed with lymphocytes obtained from three people. The majority of the DNA restore occurred throughout the first 15 min, whereas the entire restore was primarily full by 120 min after publicity. Nonetheless, some cells demonstrated no restore throughout this incubation interval whereas different cells demonstrated DNA migration patterns indicative of extra harm than that induced by the preliminary irradiation with X-rays. This system seems to be delicate and helpful for detecting harm and restore in single cells.
Zaangażowanie immunoinhibitorowego receptora PD-1 przez nowego członka rodziny B7 prowadzi do negatywnej regulacji aktywacji limfocytów.
PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice poor in PD-1 exhibit a breakdown of peripheral tolerance and exhibit a number of autoimmune options. We report right here that the ligand of PD-1 (PD-L1) is a member of the B7 gene household. Engagement of PD-1 by PD-L1 results in the inhibition of T cell receptor-mediated lymphocyte proliferation and cytokine secretion. As well as, PD-1 signaling can inhibit a minimum of suboptimal ranges of CD28-mediated costimulation. PD-L1 is expressed by antigen-presenting cells, together with human peripheral blood monocytes stimulated with interferon gamma, and activated human and murine dendritic cells.
As well as, PD-L1 is expressed in nonlymphoid tissues resembling coronary heart and lung. The relative ranges of inhibitory PD-L1 and costimulatory B7-1/B7-2 indicators on antigen-presenting cells might decide the extent of T cell activation and consequently the edge between tolerance and autoimmunity. PD-L1 expression on nonlymphoid tissues and its potential interplay with PD-1 might subsequently decide the extent of immune responses at websites of irritation.
TARGATT? Knock-in iPSC Generation (Master Cell Line) |
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| AST-1100 | Applied StemCell | 1 vial of 1X10^6 cells | Ask for price |
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Description: 6 month |
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TARGATT? Knock-in Mouse Cell Line Generation Kit (Master Cell Line) |
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| AST-7001 | Applied StemCell | 1 Kit | Ask for price |
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Description: 6 month |
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HEK-293T cells |
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| T0011002 | Addexbio | One Frozen vial | EUR 455 |
TARGATT? Knock-in CHO Generation Kit (Master Cell Line) |
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| AST-1200 | Applied StemCell | 1 Kit | Ask for price |
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Description: 12 month |
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TARGATT? Knock-in HEK293 Generation Kit (Master Cell Line) |
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| AST-1300 | Applied StemCell | 1 Kit | Ask for price |
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Description: 12 month |
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HEK-293T Telomerase Over-Expressing Cell Pellet |
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| abx069991-1Pellet | Abbexa | 1 Pellet | EUR 398 |
LCK 3'UTR GFP Stable Cell Line |
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| TU062323 | ABM | 1.0 ml | EUR 1394 |
LCK 3'UTR Luciferase Stable Cell Line |
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| TU012323 | ABM | 1.0 ml | EUR 1394 |
Lck 3'UTR GFP Stable Cell Line |
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| TU256973 | ABM | 1.0 ml | Ask for price |
Lck 3'UTR Luciferase Stable Cell Line |
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| TU206973 | ABM | 1.0 ml | Ask for price |
Lck 3'UTR GFP Stable Cell Line |
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| TU160948 | ABM | 1.0 ml | Ask for price |
Lck 3'UTR Luciferase Stable Cell Line |
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| TU110948 | ABM | 1.0 ml | Ask for price |
293RTV Cell Line |
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| RV-100 | Cell Biolabs | 1 vial | EUR 508 |
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Description: The 293RTV Cell Line is derived from the parental 293 cells but selected for attributes that increase retroviral production, including fimrer attachment and larger surface area. |
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293LTV Cell Line |
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| LTV-100 | Cell Biolabs | 1 vial | EUR 508 |
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Description: The 293LTV Cell Line is derived from the parental 293 cells but selected for attributes that increase lentiviral production, including fimrer attachment and larger surface area. |
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293AAV Cell Line |
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| AAV-100 | Cell Biolabs | 1 vial | EUR 508 |
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Description: The 293AAV Cell Line is derived from the parental 293 cells but selected for attributes that increase AAV production, including firmer attachment and larger surface area. |
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293AD Cell Line |
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| AD-100 | Cell Biolabs | 1 vial | EUR 461 |
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Description: The 293AD Cell Line is derived from the parental 293 cells but selected for attributes that increase adenovirus production, including firmer attachment and larger surface area. |
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Basic HR Targeting Vector [MCS1-LoxP-MCS2-MCS3-pA-LoxP-MCS4] for Gene Knock-In/Out |
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| HR100PA-1 | SBI | 10 ug | EUR 938 |
293/GFP Cell Line |
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| AKR-200 | Cell Biolabs | 1 vial | EUR 572 |
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Description: 293/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
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T47D/GFP Cell Line |
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| AKR-208 | Cell Biolabs | 1 vial | EUR 572 |
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Description: T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
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A549/GFP Cell Line |
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| AKR-209 | Cell Biolabs | 1 vial | EUR 572 |
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Description: A549/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
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HeLa/GFP Cell Line |
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| AKR-213 | Cell Biolabs | 1 vial | EUR 572 |
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Description: HeLa/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
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NIH3T3/GFP Cell Line |
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| AKR-214 | Cell Biolabs | 1 vial | EUR 572 |
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Description: NIH3T3/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line. |
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NIH3T3/Cas9 Cell Line |
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| AKR-5104 | Cell Biolabs | 1 vial | EUR 572 |
293/Cas9 Cell Line |
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| AKR-5110 | Cell Biolabs | 1 vial | EUR 572 |
HeLa/Cas9 Cell Line |
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| AKR-5111 | Cell Biolabs | 1 vial | EUR 572 |
Human Tyrosine-protein kinase Lck (LCK) |
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| 1-CSB-EP012806HU | Cusabio |
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Description: Recombinant Human Tyrosine-protein kinase Lck(LCK) expressed in E.coli |
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Human Tyrosine-protein kinase Lck (LCK) |
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| 1-CSB-EP012806HUa2 | Cusabio |
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Description: Recombinant Human Tyrosine-protein kinase Lck(LCK) expressed in E.coli |
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293T Transfection Kit (1 mL) |
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| P902 | 101Bio | - | Ask for price |
293T Transfection Kit (0.2 mL) |
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| P902S | 101Bio | - | Ask for price |
293T Transfection Kit (1 mL) |
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| P903 | 101Bio | - | Ask for price |
293T Transfection Kit (0.2 mL) |
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| P903S | 101Bio | - | Ask for price |
Microplate Swing-Out Centrifuge |
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| abx725026-1Unit | Abbexa | 1 Unit | EUR 1476 |
Clinical Swing-Out Centrifuge |
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| abx725027-1Unit | Abbexa | 1 Unit | EUR 1476 |
SKOV-3/Luc Cell Line |
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| AKR-232 | Cell Biolabs | 1 vial | EUR 572 |
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Description: SKOV-3/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line. |
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MCF-7/Luc Cell Line |
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| AKR-234 | Cell Biolabs | 1 vial | EUR 572 |
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Description: MCF-7/Luc Cell Line stably expresses luciferase and otherwise exhibits the same characteristics of the parental cell line. |
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OVCAR-5/RFP Cell Line |
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| AKR-254 | Cell Biolabs | 1 vial | EUR 572 |
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Description: OVCAR-5/RFP Cell Line stably expresses RFP and otherwise exhibits the same characteristics of the parental cell line. |
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Gene Knock-Out HR Targeting Vector w/Single Selection Marker (Blasticidin) and Negative Selection (TK) Against Random Integration |
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| HR720PA-1 | SBI | 10 µg | EUR 1145 |
Lck/ Rat Lck ELISA Kit |
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| ELI-38801r | Lifescience Market | 96 Tests | EUR 886 |
Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (GFP+Puro) and Negative Selection (TK) Against Random Integration |
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| HR700PA-1 | SBI | 10 µg | EUR 1145 |
Gene Knock-Out HR Targeting Vector w/Dual Selection Markers (RFP+Hygro) and Negative Selection (TK) Against Random Integration |
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| HR710PA-1 | SBI | 10 µg | EUR 1145 |
Platinum-E Retroviral Packaging Cell Line, Ecotropic |
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| RV-101 | Cell Biolabs | 1 vial | EUR 920 |
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Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-E cells contain gag, pol and env genes, allowing retroviral packaging with a single plasmid transfection. |
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Platinum-A Retroviral Packaging Cell Line, Amphotropic |
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| RV-102 | Cell Biolabs | 1 vial | EUR 920 |
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Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-A cells contain gag, pol and env genes, allowing retroviral packaging with a single plasmid transfection. |
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Platinum-GP Retroviral Packaging Cell Line, Pantropic |
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| RV-103 | Cell Biolabs | 1 vial | EUR 920 |
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Description: Conventional cells used for retrovirus packaging, such as those based on NIH3T3 cells, have limited stability and produce relatively low yields of retrovirus, mainly due to the poor expression of retroviral structure proteins (gag, pol and env) in the cells. The Platinum Retroviral Packaging Cell Lines are based on the 293T cell line. They exhibit longer stability and produce higher yields of retroviral structure proteins. Plat-GP cells contain the gag and pol genes required for retroviral packaging; an expression vector is co-transfected with a VSVG envelope vector. |
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Human Tyrosine- protein kinase Lck, LCK ELISA KIT |
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| ELI-31641h | Lifescience Market | 96 Tests | EUR 824 |
Human Tyrosine protein kinase Lck(LCK) ELISA kit |
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| E01T0623-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Tyrosine protein kinase Lck(LCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Tyrosine protein kinase Lck(LCK) ELISA kit |
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| E01T0623-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Tyrosine protein kinase Lck(LCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Tyrosine protein kinase Lck(LCK) ELISA kit |
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| E01T0623-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Tyrosine protein kinase Lck(LCK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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LCK sgRNA CRISPR Lentivector set (Human) |
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| K1201901 | ABM | 3 x 1.0 ug | EUR 339 |
Gene Knock-Out HR Targeting Vector with TK selection [MCS1-LoxP-EF1?-GFP-T2A-Puro-P2A-hsvTK-pA-LoxP-MCS2] |
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| HR210PA-1 | SBI | 10 ug | EUR 1145 |
Monoclonal p56lck / LCK Antibody (clone Lck-01), Clone: Lck-01 |
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| APR17729G | Leading Biology | 0.05mg | EUR 484 |
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Description: A Monoclonal antibody against Human p56lck / LCK (clone Lck-01). The antibodies are raised in Mouse and are from clone Lck-01. This antibody is applicable in WB and IHC-P, ICC, IP, Flo |
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Tyrosine-Protein Kinase Lck (LCK) Antibody |
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| abx159593-100ul | Abbexa | 100 ul | EUR 467 |
LCK Antibody |
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| 1-CSB-PA009795 | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000 |
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LCK Antibody |
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| 1-CSB-PA009798 | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/40000 |
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LCK Antibody |
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| 1-CSB-PA009802 | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/5000 |
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LCK Antibody |
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| 1-CSB-PA012806GA01HU | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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LCK Antibody |
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| 1-CSB-PA012806LA01HU | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000 |
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LCK Antibody |
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| 1-CSB-PA003142 | Cusabio |
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Description: A polyclonal antibody against LCK. Recognizes LCK from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000 |
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Lck Inhibitor |
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| HY-12072 | MedChemExpress | 100mg | EUR 2019 |
Lck Antibody |
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| 35363-100ul | SAB | 100ul | EUR 390 |
Lck Antibody |
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| 35446-100ul | SAB | 100ul | EUR 390 |
LCK Antibody |
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| 32644-100ul | SAB | 100ul | EUR 252 |
LCK siRNA |
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| 20-abx922340 | Abbexa |
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LCK siRNA |
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| 20-abx922341 | Abbexa |
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LCK siRNA |
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| 20-abx902944 | Abbexa |
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Lck Inhibitor |
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| A3539-1 | ApexBio | 1 mg | EUR 154 |
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Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family. |
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Lck Inhibitor |
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| A3539-5 | ApexBio | 5 mg | EUR 222 |
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Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family. |
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LCK Antibody |
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| AF5412 | Affbiotech | 200ul | EUR 304 |
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Description: LCK Antibody detects endogenous levels of total LCK. |
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Lck Antibody |
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| AF6100 | Affbiotech | 200ul | EUR 304 |
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Description: Lck Antibody detects endogenous levels of total Lck. |
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Lck Antibody |
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| AF6101 | Affbiotech | 200ul | EUR 304 |
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Description: Lck Antibody detects endogenous levels of total Lck. |
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Lck Antibody |
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| AF7694 | Affbiotech | 200ul | EUR 376 |
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Description: Lck Antibody detects endogenous levels of Lck. |
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Lck Antibody |
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| AF7695 | Affbiotech | 200ul | EUR 376 |
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Description: Lck Antibody detects endogenous levels of Lck. |
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LCK Antibody |
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| AF7696 | Affbiotech | 200ul | EUR 376 |
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Description: LCK Antibody detects endogenous levels of LCK. |
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LCK Antibody |
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| ABD6900 | Lifescience Market | 100 ug | EUR 438 |
LCK Antibody |
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| ABF5412 | Lifescience Market | 100 ug | EUR 438 |
LCK Antibody |
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| DF6900 | Affbiotech | 200ul | EUR 304 |
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Description: LCK Antibody detects endogenous levels of total LCK. |
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Lck Antibody |
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| BF0456 | Affbiotech | 200ul | EUR 376 |
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Description: Lck antibody detects endogenous levels of total Lck. |
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anti-LCK |
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| LF-PA0206 | Abfrontier | 100 ul | EUR 334 |
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Description: Rabbit polyclonal to LCK |
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Lck Antibody |
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| ABF6100 | Lifescience Market | 100 ug | EUR 438 |
Lck Antibody |
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| ABF6101 | Lifescience Market | 100 ug | EUR 438 |
anti-Lck |
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| YF-PA12927 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to Lck |
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Lck, Active |
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| 7733-5 | Biovision | EUR 370 | |
Lck Antibody |
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| 3498-100 | Biovision | EUR 316 | |
Lck Antibody |
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| 3498-30T | Biovision | EUR 146 | |
LCK antibody |
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| 20R-1997 | Fitzgerald | 50 ug | EUR 281 |
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Description: Rabbit polyclonal LCK antibody |
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LCK antibody |
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| 20R-2166 | Fitzgerald | 50 ug | EUR 281 |
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Description: Rabbit polyclonal LCK antibody |
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LCK antibody |
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| 20R-2987 | Fitzgerald | 100 ul | EUR 393 |
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Description: Rabbit polyclonal LCK antibody |
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Lck antibody |
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| 20R-1612 | Fitzgerald | 100 ug | EUR 673 |
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Description: Rabbit polyclonal Lck antibody |
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Lck antibody |
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| 20R-1613 | Fitzgerald | 100 ug | EUR 705 |
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Description: Rabbit polyclonal Lck antibody |
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